BMJ Open (Nov 2020)
Retrospective cohort study of clinical characteristics of 2199 hospitalised patients with COVID-19 in New York City
- Girish N Nadkarni,
- Zahi A Fayad,
- Benjamin S Glicksberg,
- David L Reich,
- Prem Timsina,
- Arash Kia,
- Patricia Kovatch,
- Jessica K De Freitas,
- Paul O’Reilly,
- Allan Just,
- Dennis Charney,
- Ishan Paranjpe,
- Ross O'Hagan,
- Adam J Russak,
- Anuradha Lala,
- Riccardo Miotto,
- Akhil Vaid,
- Kipp W Johnson,
- Matteo Danieletto,
- Eddye Golden,
- Dara Meyer,
- Manbir Singh,
- Sulaiman Somani,
- Arjun Kapoor,
- Sayan Manna,
- Udit Nangia,
- Suraj K Jaladanki,
- Laura M Huckins,
- Patricia Glowe,
- Robert M Freeman,
- Matthew A Levin,
- Jeffrey Jhang,
- Adolfo Firpo,
- Joseph Finkelstein,
- Judith A Aberg,
- Emilia Bagiella,
- Carol R Horowitz,
- Barbara Murphy,
- Eric J Nestler,
- V Fuster,
- Carlos Cordon-Cardo,
- Erwin P Bottinger,
- Alexander W Charney
Affiliations
- Girish N Nadkarni
- 3 Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Zahi A Fayad
- Icahn School of Medicine at Mount Sinai BioMedical Engineering and Imaging Institute, New York, New York, USA
- Benjamin S Glicksberg
- Bakar Computational Health Sciences Institute, University of California, San Francisco, CA, United States
- David L Reich
- Icahn School of Medicine at Mount Sinai Department of Anesthesiology Perioperative and Pain Medicine, New York, New York, USA
- Prem Timsina
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Arash Kia
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Patricia Kovatch
- Mount Sinai Data Warehouse, Mount Sinai Health System, New York, New York, USA
- Jessica K De Freitas
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Paul O’Reilly
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Allan Just
- Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health, New York, New York, USA
- Dennis Charney
- Icahn School of Medicine at Mount Sinai Department of Psychiatry, New York, New York, USA
- Ishan Paranjpe
- 3 Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Ross O'Hagan
- 3 Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Adam J Russak
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Anuradha Lala
- The Zena and Michael A. Wiener Cardiovascular Institute, New York, New York, USA
- Riccardo Miotto
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Akhil Vaid
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Kipp W Johnson
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Matteo Danieletto
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Eddye Golden
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Dara Meyer
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Manbir Singh
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Sulaiman Somani
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Arjun Kapoor
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Sayan Manna
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Udit Nangia
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Suraj K Jaladanki
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Laura M Huckins
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Patricia Glowe
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Robert M Freeman
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Matthew A Levin
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Jeffrey Jhang
- Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Adolfo Firpo
- Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Joseph Finkelstein
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Judith A Aberg
- Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Emilia Bagiella
- The Zena and Michael A. Wiener Cardiovascular Institute, New York, New York, USA
- Carol R Horowitz
- Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Barbara Murphy
- Icahn School of Medicine at Mount Sinai Department of Medicine, New York, New York, USA
- Eric J Nestler
- Icahn School of Medicine at Mount Sinai Friedman Brain Institute, New York, New York, USA
- V Fuster
- Department of Medicine, Division of Cardiology, Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Carlos Cordon-Cardo
- Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Erwin P Bottinger
- The Hasso Plattner Institute for Digital Health at Mount Sinai, New York, New York, USA
- Alexander W Charney
- Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- DOI
- https://doi.org/10.1136/bmjopen-2020-040736
- Journal volume & issue
-
Vol. 10,
no. 11
Abstract
Objective The COVID-19 pandemic is a global public health crisis, with over 33 million cases and 999 000 deaths worldwide. Data are needed regarding the clinical course of hospitalised patients, particularly in the USA. We aimed to compare clinical characteristic of patients with COVID-19 who had in-hospital mortality with those who were discharged alive.Design Demographic, clinical and outcomes data for patients admitted to five Mount Sinai Health System hospitals with confirmed COVID-19 between 27 February and 2 April 2020 were identified through institutional electronic health records. We performed a retrospective comparative analysis of patients who had in-hospital mortality or were discharged alive.Setting All patients were admitted to the Mount Sinai Health System, a large quaternary care urban hospital system.Participants Participants over the age of 18 years were included.Primary outcomes We investigated in-hospital mortality during the study period.Results A total of 2199 patients with COVID-19 were hospitalised during the study period. As of 2 April, 1121 (51%) patients remained hospitalised, and 1078 (49%) completed their hospital course. Of the latter, the overall mortality was 29%, and 36% required intensive care. The median age was 65 years overall and 75 years in those who died. Pre-existing conditions were present in 65% of those who died and 46% of those discharged. In those who died, the admission median lymphocyte percentage was 11.7%, D-dimer was 2.4 μg/mL, C reactive protein was 162 mg/L and procalcitonin was 0.44 ng/mL. In those discharged, the admission median lymphocyte percentage was 16.6%, D-dimer was 0.93 μg/mL, C reactive protein was 79 mg/L and procalcitonin was 0.09 ng/mL.Conclusions In our cohort of hospitalised patients, requirement of intensive care and mortality were high. Patients who died typically had more pre-existing conditions and greater perturbations in inflammatory markers as compared with those who were discharged.
