OncoTargets and Therapy (Apr 2016)

Genetic association between interluekin-4 rs2243250 polymorphism and gastric cancer susceptibility: evidence based on a meta-analysis

  • Zhang C,
  • Huang JY,
  • He ZQ,
  • Weng H

Journal volume & issue
Vol. 2016, no. Issue 1
pp. 2403 – 2408

Abstract

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Chi Zhang,1,* Jing-Yu Huang,1,* Zi-Qi He,2,* Hong Weng3 1Department of Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 3Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China *These authors contributed equally to this work Purpose: Numerous studies have suggested that the interleukin-4 (IL-4) rs2243250 polymorphism is associated with gastric cancer susceptibility. However, the results were inconsistent. Hence, we carried out a meta-analysis to confirm the conclusion.Methods: We searched PubMed, Embase, CBM, CNKI, and Wanfang Data to identify relevant studies up to August 20, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association between IL-4 rs2243250 polymorphism and gastric cancer susceptibility. All the statistical analyses were performed with Stata 12.0 software.Results: A total of eleven published case–control studies were identified, including 2,247 gastric cancer patients and 3,370 controls. Overall, no significant association between IL-4 rs2243250 polymorphism and gastric cancer susceptibility was observed in this meta-analysis (T vs C: OR =1.05, 95% CI =0.95–1.17; TT vs CC: OR =1.20, 95% CI =0.89–1.63; CT vs CC: OR =1.14, 95% CI =0.87–1.48; TT + CT vs CC: OR =1.13, 95% CI =0.89–1.44; TT vs CT + CC: OR =1.02, 95% CI =0.88–1.20). Similar results were found in subgroup analyses according to ethnicity and Hardy–Weinberg equilibrium in controls.Conclusion: This meta-analysis suggests that IL-4 rs2243250 polymorphism may not be associated with gastric cancer susceptibility. Further studies are needed to validate this conclusion. Keywords: interleukin-4, meta-analysis, polymorphism, genetic, stomach neoplasms

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