Antibiotic Resistance Patterns in Invasive Group B Streptococcal Isolates

Mei L. Castor; Cynthia G. Whitney; Kathryn Como-Sabetti; Richard R. Facklam; Patricia Ferrieri; Joanne M. Bartkus; Billie A. Juni; Paul R. Cieslak; Monica M. Farley; Nellie B. Dumas; Stephanie J. Schrag; Ruth Lynfield

doi:10.1155/2008/727505

Infectious Diseases in Obstetrics and Gynecology (Jan 2008)

Antibiotic Resistance Patterns in Invasive Group B Streptococcal Isolates

Mei L. Castor,
Cynthia G. Whitney,
Kathryn Como-Sabetti,
Richard R. Facklam,
Patricia Ferrieri,
Joanne M. Bartkus,
Billie A. Juni,
Paul R. Cieslak,
Monica M. Farley,
Nellie B. Dumas,
Stephanie J. Schrag,
Ruth Lynfield

Affiliations

Mei L. Castor: Infectious Disease Epidemiology, Prevention and Control Division, Minnesota Department of Health, 625 Robert Street North, P.O. Box 64975, Saint Paul, MN 55164, USA
Cynthia G. Whitney: Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Kathryn Como-Sabetti: Infectious Disease Epidemiology, Prevention and Control Division, Minnesota Department of Health, 625 Robert Street North, P.O. Box 64975, Saint Paul, MN 55164, USA
Richard R. Facklam: Streptococcus Laboratory, Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Patricia Ferrieri: Pediatrics and Laboratory Medicine and Pathology, Clinical Microbiology Laboratory, University of Minnesota Medical School, 420 Delaware Street SE Minneapolis, MN 55455, USA
Joanne M. Bartkus: Public Health Laboratory Division, Minnesota Department of Health, 601 Robert Street North, P.O. Box 64899, Saint Paul, MN 55164, USA
Billie A. Juni: Public Health Laboratory Division, Minnesota Department of Health, 601 Robert Street North, P.O. Box 64899, Saint Paul, MN 55164, USA
Paul R. Cieslak: Public Health Division, Oregon Department of Human Services, 800 NE Oregon Street, Portland, OR 97232, USA
Monica M. Farley: Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, 1670 Clairmont Rd, Station 151 Decatur, GA 30033, USA
Nellie B. Dumas: Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
Stephanie J. Schrag: Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Ruth Lynfield: Infectious Disease Epidemiology, Prevention and Control Division, Minnesota Department of Health, 625 Robert Street North, P.O. Box 64975, Saint Paul, MN 55164, USA

DOI: https://doi.org/10.1155/2008/727505
Journal volume & issue: Vol. 2008

Abstract

Read online

Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996—2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P<.001). Clindamycin resistance increased from 10.5% to 15.0% (X2 for trend 12.70; P<.001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X2 for trend 55.46; P<.001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.

Published in Infectious Diseases in Obstetrics and Gynecology

ISSN: 1064-7449 (Print); 1098-0997 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Gynecology and obstetrics; Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://onlinelibrary.wiley.com/journal/7281

About the journal