Non-Invasive Optical Screening of <italic>Streptococcus Pneumonia</italic> Based Inflammatory Changes of the Tympanic Membrane and Mastoid Mucosa in Guinea Pig Otitis Media Using Optical Coherence Tomography

Ruchire Eranga Wijesinghe; Jaeyul Lee; Deokmin Jeon; Pilun Kim; Sangyeob Han; Junsoo Lee; Daewoon Seong; Dong-Eun Lee; Jeong Hun Jang; Mansik Jeon; Jeehyun Kim

doi:10.1109/JPHOT.2020.3012497

IEEE Photonics Journal (Jan 2020)

Non-Invasive Optical Screening of <italic>Streptococcus Pneumonia</italic> Based Inflammatory Changes of the Tympanic Membrane and Mastoid Mucosa in Guinea Pig Otitis Media Using Optical Coherence Tomography

Ruchire Eranga Wijesinghe,
Jaeyul Lee,
Deokmin Jeon,
Pilun Kim,
Sangyeob Han,
Junsoo Lee,
Daewoon Seong,
Dong-Eun Lee,
Jeong Hun Jang,
Mansik Jeon,
Jeehyun Kim

Affiliations

Ruchire Eranga Wijesinghe: College of Engineering, Department of Biomedical Engineering, Kyungil University, Gyeongsangbuk-do, South Korea
Jaeyul Lee: College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Deokmin Jeon: College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Pilun Kim: College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Sangyeob Han: College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Junsoo Lee: ORCiD; College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Daewoon Seong: College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Dong-Eun Lee: ORCiD; School of Architecture and Civil Engineering, Kyungpook National University, Daegu, Korea
Jeong Hun Jang: Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Ajou University, Gyeunggi-do, South Korea
Mansik Jeon: ORCiD; College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea
Jeehyun Kim: College of IT Engineering, School of Electronics Engineering, Kyungpook National University, Daegu, Korea

DOI: https://doi.org/10.1109/JPHOT.2020.3012497
Journal volume & issue: Vol. 12, no. 4
pp. 1 – 11

Abstract

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The accurate screening of otitis media (OM) lies in clarifying the numerous confounding and quantitative factors that are discovered during primary inspections. Increased awareness about bacterial biofilms and inflammation has allowed researchers to develop a better understanding of the bacterial infections that occur in the middle ear. In this study, four live guinea pigs were inoculated with Streptococcus pneumonia to induce OM-related inflammatory changes. Since optical techniques have been effectively used for diagnosis in medicine, low-coherence interferometry-based optical coherence tomography (OCT) was employed for depth-resolved high-resolution data screening. Multiple locations of the tympanic membrane (TM), mastoid mucosa, and round window membrane were examined to assess inflammatory changes. We performed qualitative assessments and thickness quantifications and investigated the variations due to adverse inflammatory affects. The findings of the present study provide a better understanding of S. pneumonia bacteria caused inflammatory changes in middle ear and it further provides a fundamental platform for future clinical utility.

Published in IEEE Photonics Journal

ISSN: 1943-0655 (Online)
Publisher: IEEE
Country of publisher: United States
LCC subjects: Technology: Engineering (General). Civil engineering (General): Applied optics. Photonics; Science: Physics: Optics. Light
Website: http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?punumber=4563994

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