Multimodality imaging approach in a case of vascular toxicity caused by cabozantinib

Georgios Benetos, MD, FESC; Angeliki Vakka, MD; Vasiliki Kalogera, MD; Eirini Solomou, MD; Lefki Nikolopoulou, MD; Vasiliki Katsi, MD; Maria Drakopoulou, MD; Constantinos Tsioufis, MD; Konstantinos Toutouzas, MD

Radiology Case Reports (Jan 2024)

Multimodality imaging approach in a case of vascular toxicity caused by cabozantinib

Georgios Benetos, MD, FESC,
Angeliki Vakka, MD,
Vasiliki Kalogera, MD,
Eirini Solomou, MD,
Lefki Nikolopoulou, MD,
Vasiliki Katsi, MD,
Maria Drakopoulou, MD,
Constantinos Tsioufis, MD,
Konstantinos Toutouzas, MD

Affiliations

Georgios Benetos, MD, FESC: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece; Cardiac CT Department, Lefkos Stavros Clinic, Athens, Greece; Corresponding author.
Angeliki Vakka, MD: Third Department of Internal Medicine, General Hospital of Nikaia, Piraeus, Greece
Vasiliki Kalogera, MD: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece
Eirini Solomou, MD: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece
Lefki Nikolopoulou, MD: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece
Vasiliki Katsi, MD: Cardiology Department, Hippokration Hospital, Athens, Greece
Maria Drakopoulou, MD: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece
Constantinos Tsioufis, MD: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece
Konstantinos Toutouzas, MD: First Department of Cardiology, Hippokration Hospital, National & Kapodistrian University of Athens, Athens, Greece

Journal volume & issue: Vol. 19, no. 1
pp. 62 – 65

Abstract

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Vascular toxicity caused by cancer treatment can present as vasospasm, arterial thrombosis, and accelerated atherosclerosis. We report a case of a 60-year-old man with metastatic renal cell carcinoma under cabozantinib treatment for 3 years who presented to the hospital with relapsing episodes of rest angina. Due to the presence of ST depression in the 12-lead electrocardiogram and elevated troponin, a non-ST-segment elevation myocardial infarction was suspected. The patient underwent invasive coronary angiography, which revealed extended coronary artery spasm, and it subsided totally after nitrate administration. One year later, the patient presented again at the cardio-oncology outpatient clinic, reporting relapsing episodes of angina during the previous month. Coronary computed tomography angiography was performed, and it revealed 2 subsequent 70%-99% stenosis in OM1. To our knowledge, this is the first case of a patient treated with cabozantinib presenting with coronary artery spasm and accelerated atherosclerosis, in which a multimodality imaging approach was followed.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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