Ability of 68Ga‐PSMA PET/CT SUVmax to differentiate ISUP GG2 from GG3 in intermediate‐risk prostate cancer: A single‐center retrospective study of 147 patients

Abstract

Abstract Objective To evaluate the ability of 68Ga‐PSMA PET/CT maximum standard uptake value (SUVmax) to distinguish prostate cancer (PCa) International Society of Urological Pathology ISUP grade group (GG) 2 and GG3. Methods The PET/CT images and data of 147 patients were analyzed retrospectively, and the SUVmax of the index lesions were measured. The receiver operating characteristic curve was used to analyze the diagnostic value of PET/CT for PCa. The correlation between SUVmax and ISUP GG was analyzed. A logistic regression model was established with SUVmax and was validated to predict its value of diagnosing intermediate‐ and high‐risk PCa (ihPCa). Results Of the 147 patients, 112 cases were PCa (76.2%), and 35 cases were benign lesions (23.8%). There was a significant difference between the benign and the malignant groups (p 0.05). The specificity and the positive predictive value of 68Ga‐PSMA PET/CT in the diagnosis of PCa were 97% and 99% with cut‐off SUVmax of 6.94, while the specificity and the positive predictive value of ihPCa were 95% and 96% with cut‐off SUVmax of 10.12. Conclusion 68Ga‐PSMA PET/CT can reliably distinguish GG2 from GG3 PCa.

Keywords

• positron emission tomography
• prostate cancer
• prostate‐specific membrane antigen