Bulletin of the National Research Centre (Aug 2023)

Isothermal calorimetry calscreener in the metabolism gauge of human malignant neoplastic cells: a burgeoning nexus in cancer biochemical metrology and diagnostics

  • Michael Tosin Bayode,
  • Mercy Adewumi Alabi,
  • Temitope Abraham Ibisanmi,
  • Ayomide Faith Okiti,
  • Olabisi Omowumi Adebisi,
  • Philemon Olayemi Aro,
  • Ayoola Emmanuel Awode,
  • Oyindamola Sukurat Lawal,
  • Olamide Joshua Babatunde,
  • Gladys Oluwafisayo Adenikinju

DOI
https://doi.org/10.1186/s42269-023-01097-8
Journal volume & issue
Vol. 47, no. 1
pp. 1 – 11

Abstract

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Abstract Background At present, the function of isothermal microcalorimetry (IMC) calscreener in detecting alterations in the metabolic pathways of cancer cells remains unexplored. We disclosed the shortcomings of current screening methods and the need for precise and dependable instruments in the detection and informed treatment of cancer via the IMC in relation to the experimental procedures required to obtain accurate results. Main body of abstract We examined the intricate technical aspects of isothermal calorimetry. The application of the IMC calscreener in cancer research is then discussed in depth, including how it can be used to evaluate the efficacy of treatments, identify metabolic inhibitors, and assess metabolic rates. We also investigated the diagnostic potential of isothermal calorimetry, particularly for early cancer detection and tracing therapy efficacy. Conclusions General findings shed light on the present issues and potential approaches for isothermal calorimetry application in cancer research and diagnosis. We underline the potential for isothermal calorimetry to fundamentally alter how to understand and treat cancer, as well as the need for additional studies to maximize its application in clinical settings. This in turn offers a thorough and fascinating account of the emerging relationship between isothermal calorimetry and cancer biochemistry, as well as its potential to revolutionize cancer detection and therapy.

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