Nature Communications (Jul 2020)
Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd
Abstract
Transcription-repair coupling factors (TRCFs) are large ATPases that mediate the preferential repair of the transcribed DNA strand. Here the authors reveal the cryo-EM structure of DNA-bound Mfd, the bacterial TRCF, and provide molecular insights into its mode of action.