RUDN Journal of Medicine (Dec 2014)

Immunogenetic markers for ulcerative colitis in adult population of moscow region

  • D S Stavtsev,
  • T A Astrelina,
  • M M Azova,
  • O A Mayorova,
  • V J Zinkin,
  • L L Lebedeva,
  • T V Pukhlikova,
  • A A Chumak,
  • O V Knyazev

Journal volume & issue
Vol. 0, no. 3
pp. 53 – 59


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The article presents the results of the study of the genetic polymorphism of HLA-antigens in 65 adult patients with ulcerative colitis (UC) living in Moscow region. It was found that certain groups of HLA alleles are associated with the pathogenesis of UC. Immunogenetic factors of predisposition and sustainability to this disease depending on gender and age were revealed. The relationship of immunogenetic factors with clinical forms of the disease, course of the UC and response to therapy with glucocorticoids were shown.