Nature Communications (Apr 2019)
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan
- Dan-Qian Chen,
- Gang Cao,
- Hua Chen,
- Christos P. Argyopoulos,
- Hui Yu,
- Wei Su,
- Lin Chen,
- David C. Samuels,
- Shougang Zhuang,
- George P. Bayliss,
- Shilin Zhao,
- Xiao-Yong Yu,
- Nosratola D. Vaziri,
- Ming Wang,
- Dan Liu,
- Jia-Rong Mao,
- Shi-Xing Ma,
- Jin Zhao,
- Yuan Zhang,
- You-Quan Shang,
- Huining Kang,
- Fei Ye,
- Xiao-Hong Cheng,
- Xiang-Ri Li,
- Li Zhang,
- Mei-Xia Meng,
- Yan Guo,
- Ying-Yong Zhao
Affiliations
- Dan-Qian Chen
- Faculty of Life Science & Medicine, Northwest University
- Gang Cao
- School of Pharmacy, Zhejiang Chinese Medical University
- Hua Chen
- Faculty of Life Science & Medicine, Northwest University
- Christos P. Argyopoulos
- Department of Internal Medicine, University of New Mexico
- Hui Yu
- Department of Internal Medicine, University of New Mexico
- Wei Su
- Department of Nephrology, Baoji Central Hospital
- Lin Chen
- Faculty of Life Science & Medicine, Northwest University
- David C. Samuels
- Department of Biomedical Informatics, Vanderbilt University Medical Center
- Shougang Zhuang
- Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine
- George P. Bayliss
- Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University
- Shilin Zhao
- Department of Biomedical Informatics, Vanderbilt University Medical Center
- Xiao-Yong Yu
- Department of Nephrology, Affiliated Hospital of Shaanxi Institute of Traditional Chinese Medicine
- Nosratola D. Vaziri
- Division of Nephrology and Hypertension, School of Medicine, University of California Irvine
- Ming Wang
- Faculty of Life Science & Medicine, Northwest University
- Dan Liu
- Faculty of Life Science & Medicine, Northwest University
- Jia-Rong Mao
- Department of Nephrology, Affiliated Hospital of Shaanxi Institute of Traditional Chinese Medicine
- Shi-Xing Ma
- Department of Nephrology, Baoji Central Hospital
- Jin Zhao
- Department of Nephrology
- Yuan Zhang
- Department of Nephrology
- You-Quan Shang
- Department of Nephrology, Baoji Central Hospital
- Huining Kang
- Department of Internal Medicine, University of New Mexico
- Fei Ye
- Department of Biomedical Informatics, Vanderbilt University Medical Center
- Xiao-Hong Cheng
- Department of Nephrology, Affiliated Hospital of Shaanxi Institute of Traditional Chinese Medicine
- Xiang-Ri Li
- School of Chinese Materia Medica, Beijing University of Chinese Medicine
- Li Zhang
- Department of Nephrology
- Mei-Xia Meng
- Department of Nephrology
- Yan Guo
- Faculty of Life Science & Medicine, Northwest University
- Ying-Yong Zhao
- Faculty of Life Science & Medicine, Northwest University
- DOI
- https://doi.org/10.1038/s41467-019-09329-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Accurate monitoring of chronic kidney disease (CKD) progression is essential for efficient disease management. Here Chen et al. identify five serum metabolites in patients with stage 1–5 CKD whose levels associate with disease progression, and find that 5-methoxytryptophan and its regulatory enzyme TPH-1 exert anti-fibrotic effects in mouse models of kidney injury.
