QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity

• Mandelie van der Walt,
• Dalton S. Möller,
• Rosalind J. van Wyk,
• Philip M. Ferguson,
• Charlotte K. Hind,
• Melanie Clifford,
• Phoebe Do Carmo Silva,
• J. Mark Sutton,
• A. James Mason,
• Megan J. Bester,
• Anabella R. M. Gaspar

Affiliations

Mandelie van der Walt

Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa

Dalton S. Möller

Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa

Rosalind J. van Wyk

Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa

Philip M. Ferguson

Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King’s College London, London, United Kingdom

Charlotte K. Hind

Antimicrobial Discovery Development and Diagnostics, Vaccine Evaluation and Development Centre, UK Health Security Agency, Salisbury, United Kingdom

Melanie Clifford

Antimicrobial Discovery Development and Diagnostics, Vaccine Evaluation and Development Centre, UK Health Security Agency, Salisbury, United Kingdom

Phoebe Do Carmo Silva

Antimicrobial Discovery Development and Diagnostics, Vaccine Evaluation and Development Centre, UK Health Security Agency, Salisbury, United Kingdom

J. Mark Sutton

Antimicrobial Discovery Development and Diagnostics, Vaccine Evaluation and Development Centre, UK Health Security Agency, Salisbury, United Kingdom

A. James Mason

Institute of Pharmaceutical Science, School of Cancer & Pharmaceutical Science, King’s College London, London, United Kingdom

Megan J. Bester

Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa

Anabella R. M. Gaspar

Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa