Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function

Keiichi Katsumoto; Siham Yennek; Chunguang Chen; Luis Fernando Delgadillo Silva; Sofia Traikov; Dror Sever; Ajuna Azad; Jingdong Shan; Seppo Vainio; Nikolay Ninov; Stephan Speier; Anne Grapin-Botton

doi:10.1038/s41467-022-33841-5

Nature Communications (Oct 2022)

Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function

Keiichi Katsumoto,
Siham Yennek,
Chunguang Chen,
Luis Fernando Delgadillo Silva,
Sofia Traikov,
Dror Sever,
Ajuna Azad,
Jingdong Shan,
Seppo Vainio,
Nikolay Ninov,
Stephan Speier,
Anne Grapin-Botton

Affiliations

Keiichi Katsumoto: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Siham Yennek: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Chunguang Chen: Institute of Physiology, Faculty of Medicine, Technische Universität Dresden
Luis Fernando Delgadillo Silva: Center for Regenerative Therapies (CRTD)
Sofia Traikov: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)
Dror Sever: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Ajuna Azad: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Jingdong Shan: Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu
Seppo Vainio: Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu
Nikolay Ninov: Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, Helmholtz Zentrum München
Stephan Speier: Institute of Physiology, Faculty of Medicine, Technische Universität Dresden
Anne Grapin-Botton: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)

DOI: https://doi.org/10.1038/s41467-022-33841-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Diabetes is characterized by loss or dysfunction of pancreatic β-cells. Here the authors show that the signalling protein WNT4 is heterogeneously activated by β-cells during their postnatal maturation with WNT4 positive cells being more mature, and that inactivating WNT4 in β-cells after maturation impairs beta-cell function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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