Nature Communications (Feb 2021)
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes
- Adam B. Weiner,
- Thiago Vidotto,
- Yang Liu,
- Adrianna A. Mendes,
- Daniela C. Salles,
- Farzana A. Faisal,
- Sanjana Murali,
- Matthew McFarlane,
- Eddie L. Imada,
- Xin Zhao,
- Ziwen Li,
- Elai Davicioni,
- Luigi Marchionni,
- Arul M. Chinnaiyan,
- Stephen J. Freedland,
- Daniel E. Spratt,
- Jennifer D. Wu,
- Tamara L. Lotan,
- Edward M. Schaeffer
Affiliations
- Adam B. Weiner
- Department of Urology, Northwestern University Feinberg School of Medicine
- Thiago Vidotto
- Department of Pathology, Johns Hopkins University School of Medicine
- Yang Liu
- Decipher Biosciences
- Adrianna A. Mendes
- Department of Pathology, Johns Hopkins University School of Medicine
- Daniela C. Salles
- Department of Pathology, Johns Hopkins University School of Medicine
- Farzana A. Faisal
- Brady Urological Institute, Johns Hopkins University School of Medicine
- Sanjana Murali
- Department of Pathology, Johns Hopkins University School of Medicine
- Matthew McFarlane
- Department of Radiation Oncology, University of Michigan
- Eddie L. Imada
- Department of Oncology, Johns Hopkins University School of Medicine
- Xin Zhao
- Decipher Biosciences
- Ziwen Li
- Decipher Biosciences
- Elai Davicioni
- Decipher Biosciences
- Luigi Marchionni
- Department of Oncology, Johns Hopkins University School of Medicine
- Arul M. Chinnaiyan
- Department of Pathology, University of Michigan
- Stephen J. Freedland
- Division of Urology, Department of Surgery, Cedars-Sinai Medical Center
- Daniel E. Spratt
- Department of Radiation Oncology, University of Michigan
- Jennifer D. Wu
- Department of Urology, Northwestern University Feinberg School of Medicine
- Tamara L. Lotan
- Department of Pathology, Johns Hopkins University School of Medicine
- Edward M. Schaeffer
- Department of Urology, Northwestern University Feinberg School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21245-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
A recent report suggested Black men with prostate cancer were more responsive to immunotherapy. Here, the authors analysed prostate cancer gene expression profiles and show tumours from Black men and men with African ancestry have an increased proportion of plasma cells compared to those of White men and this correlates with improved outcome following treatment.
