Nature Communications (Aug 2016)

TNIK inhibition abrogates colorectal cancer stemness

  • Mari Masuda,
  • Yuko Uno,
  • Naomi Ohbayashi,
  • Hirokazu Ohata,
  • Ayako Mimata,
  • Mutsuko Kukimoto-Niino,
  • Hideki Moriyama,
  • Shigeki Kashimoto,
  • Tomoko Inoue,
  • Naoko Goto,
  • Koji Okamoto,
  • Mikako Shirouzu,
  • Masaaki Sawa,
  • Tesshi Yamada

DOI
https://doi.org/10.1038/ncomms12586
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.