Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against <i>Staphylococcus aureus</i>
Marta Ferrera-Suanzes,
Victoria Prieto,
Antonio J. Medina-Olivera,
José Manuel Botubol-Ares,
Fátima Galán-Sánchez,
Manuel A. Rodríguez-Iglesias,
Rosario Hernández-Galán,
María Jesús Durán-Peña
Affiliations
Marta Ferrera-Suanzes
Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro s/n, Torre Sur, 4<sup>a</sup>; planta, University of Cádiz, 11510 Puerto Real, 11009 Cádiz, Spain
Victoria Prieto
Department of Biomedicine, Biotechnology and Public Health, Hospital Puerta del Mar, University of Cádiz, 11009 Cádiz, Spain
Antonio J. Medina-Olivera
Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro s/n, Torre Sur, 4<sup>a</sup>; planta, University of Cádiz, 11510 Puerto Real, 11009 Cádiz, Spain
José Manuel Botubol-Ares
Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro s/n, Torre Sur, 4<sup>a</sup>; planta, University of Cádiz, 11510 Puerto Real, 11009 Cádiz, Spain
Fátima Galán-Sánchez
Department of Biomedicine, Biotechnology and Public Health, Hospital Puerta del Mar, University of Cádiz, 11009 Cádiz, Spain
Manuel A. Rodríguez-Iglesias
Department of Biomedicine, Biotechnology and Public Health, Hospital Puerta del Mar, University of Cádiz, 11009 Cádiz, Spain
Rosario Hernández-Galán
Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro s/n, Torre Sur, 4<sup>a</sup>; planta, University of Cádiz, 11510 Puerto Real, 11009 Cádiz, Spain
María Jesús Durán-Peña
Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro s/n, Torre Sur, 4<sup>a</sup>; planta, University of Cádiz, 11510 Puerto Real, 11009 Cádiz, Spain
Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) have become serious infections in humans and ruminants. S. aureus strains are showing rapid changes to develop resistance in traditional antibiotic-containing systems. In the continuous fierce fight against the emergent multi-drug resistant bacterial strains, straightforward and scalable synthetic procedures to produce new active molecules are in demand. Analysis of molecular properties points to degraded limonoids as promising candidates. In this article, we report a simple synthetic approach to obtain degraded limonoid analogs as scaffolds for new antibacterial molecules. The minimum inhibitory concentrations against S. aureus were evaluated for the stereoisomer mixtures by the broth microdilution method. Analysis of results showed that the acetylated derivatives were the most active of them all.
