Multi-band MEG signatures of BOLD connectivity reorganization during visuospatial attention
Chiara Favaretto,
Sara Spadone,
Carlo Sestieri,
Viviana Betti,
Angelo Cenedese,
Stefania Della Penna,
Maurizio Corbetta
Affiliations
Chiara Favaretto
Department of Neuroscience and Padova Neuroscience Center, University of Padova, 35128 Padova, Italy; Padova Neuroscience Center, PNC, 35131 Padova, Italy; Corresponding authors.
Sara Spadone
Department of Neuroscience, Imaging and Clinical Sciences – and ITAB, Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
Carlo Sestieri
Department of Neuroscience, Imaging and Clinical Sciences – and ITAB, Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
Viviana Betti
Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy; IRCCS Fondazione Santa Lucia, 00179 Rome, Italy
Angelo Cenedese
Department of Information Engineering, University of Padova, 35131 Padova, Italy
Stefania Della Penna
Department of Neuroscience, Imaging and Clinical Sciences – and ITAB, Institute for Advanced Biomedical Technologies, G. d'Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
Maurizio Corbetta
Department of Neuroscience and Padova Neuroscience Center, University of Padova, 35128 Padova, Italy; Department of Neurology, Radiology, Neuroscience, and Biomedical Engineering Washington University Saint Louis, MO 63110, USA; Venetian Institute of Molecular Medicine, VIMM, 35128 Padova, Italy; Padova Neuroscience Center, PNC, 35131 Padova, Italy; Corresponding authors.
The functional architecture of the resting brain, as measured with the blood oxygenation level-dependent functional connectivity (BOLD-FC), is slightly modified during task performance. In previous work, we reported behaviorally relevant BOLD-FC modulations between visual and dorsal attention regions when subjects performed a visuospatial attention task as compared to central fixation (Spadone et al., 2015).Here we use magnetoencephalography (MEG) in the same group of subjects to identify the electrophysiological correlates of the BOLD-FC modulation found in our previous work. While BOLD-FC topography, separately at rest and during visual attention, corresponded to neuromagnetic Band-Limited Power (BLP) correlation in the alpha and beta bands (8–30 Hz), BOLD-FC modulations evoked by performing the visual attention task (Spadone et al. 2015) did not match any specific oscillatory band BLP modulation. Conversely, following the application of an orthogonal spatial decomposition that identifies common inter-subject co-variations, we found that attention–rest BOLD-FC modulations were recapitulated by multi-spectral BLP-FC components. Notably, individual variability of alpha connectivity between Frontal Eye Fields and visual occipital regions, jointly with decreased interaction in the Visual network, correlated with visual discrimination accuracy. In summary, task-rest BOLD connectivity modulations match multi-spectral MEG BLP connectivity.
