Adrenal hormones mediate disease tolerance in malaria

Leen Vandermosten; Thao-Thy Pham; Sofie Knoops; Charlotte De Geest; Natacha Lays; Kristof Van der Molen; Christopher J. Kenyon; Manu Verma; Karen E. Chapman; Frans Schuit; Karolien De Bosscher; Ghislain Opdenakker; Philippe E. Van den Steen

doi:10.1038/s41467-018-06986-5

Nature Communications (Oct 2018)

Adrenal hormones mediate disease tolerance in malaria

Leen Vandermosten,
Thao-Thy Pham,
Sofie Knoops,
Charlotte De Geest,
Natacha Lays,
Kristof Van der Molen,
Christopher J. Kenyon,
Manu Verma,
Karen E. Chapman,
Frans Schuit,
Karolien De Bosscher,
Ghislain Opdenakker,
Philippe E. Van den Steen

Affiliations

Leen Vandermosten: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Thao-Thy Pham: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Sofie Knoops: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Charlotte De Geest: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Natacha Lays: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Kristof Van der Molen: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Christopher J. Kenyon: Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh
Manu Verma: Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh
Karen E. Chapman: Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh
Frans Schuit: Gene Expression Unit, Department of Cellular and Molecular Medicine, KU Leuven
Karolien De Bosscher: Nuclear Receptor Lab, Receptor Research Laboratories, VIB Center for Medical Biotechnology, Ghent University
Ghislain Opdenakker: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven
Philippe E. Van den Steen: Laboratory of Immunobiology, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven

DOI: https://doi.org/10.1038/s41467-018-06986-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 18

Abstract

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Disease tolerance mechanisms counter the negative effects of infection without decreasing the pathogen load. Here, the authors show that in mouse models of malaria, such disease tolerance can be conferred by adrenal hormones, by preventing excessive inflammation and hypoglycemia.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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