Nature Communications (Jan 2021)
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
- Jing-Hui Tian,
- Nita Patel,
- Robert Haupt,
- Haixia Zhou,
- Stuart Weston,
- Holly Hammond,
- James Logue,
- Alyse D. Portnoff,
- James Norton,
- Mimi Guebre-Xabier,
- Bin Zhou,
- Kelsey Jacobson,
- Sonia Maciejewski,
- Rafia Khatoon,
- Malgorzata Wisniewska,
- Will Moffitt,
- Stefanie Kluepfel-Stahl,
- Betty Ekechukwu,
- James Papin,
- Sarathi Boddapati,
- C. Jason Wong,
- Pedro A. Piedra,
- Matthew B. Frieman,
- Michael J. Massare,
- Louis Fries,
- Karin Lövgren Bengtsson,
- Linda Stertman,
- Larry Ellingsworth,
- Gregory Glenn,
- Gale Smith
Affiliations
- Jing-Hui Tian
- Novavax, Inc.
- Nita Patel
- Novavax, Inc.
- Robert Haupt
- University of Maryland, School of Medicine
- Haixia Zhou
- Novavax, Inc.
- Stuart Weston
- University of Maryland, School of Medicine
- Holly Hammond
- University of Maryland, School of Medicine
- James Logue
- University of Maryland, School of Medicine
- Alyse D. Portnoff
- Novavax, Inc.
- James Norton
- Novavax, Inc.
- Mimi Guebre-Xabier
- Novavax, Inc.
- Bin Zhou
- Novavax, Inc.
- Kelsey Jacobson
- Novavax, Inc.
- Sonia Maciejewski
- Novavax, Inc.
- Rafia Khatoon
- Novavax, Inc.
- Malgorzata Wisniewska
- Novavax, Inc.
- Will Moffitt
- Novavax, Inc.
- Stefanie Kluepfel-Stahl
- Novavax, Inc.
- Betty Ekechukwu
- Novavax, Inc.
- James Papin
- Department of Pathology, Division of Comparative Medicine, University of Oklahoma, Health Sciences Center
- Sarathi Boddapati
- Catalent Cell & Gene Therapy
- C. Jason Wong
- Catalent Cell & Gene Therapy
- Pedro A. Piedra
- Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine
- Matthew B. Frieman
- University of Maryland, School of Medicine
- Michael J. Massare
- Novavax, Inc.
- Louis Fries
- Novavax, Inc.
- Karin Lövgren Bengtsson
- Novavax AB
- Linda Stertman
- Novavax AB
- Larry Ellingsworth
- Novavax, Inc.
- Gregory Glenn
- Novavax, Inc.
- Gale Smith
- Novavax, Inc.
- DOI
- https://doi.org/10.1038/s41467-020-20653-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.
