Characterizing low-frequency artifacts during transcranial temporal interference stimulation (tTIS)

Jill von Conta; Florian H. Kasten; Branislava Ćurčić-Blake; Klaus Schellhorn; Christoph S. Herrmann

Neuroimage: Reports (Sep 2022)

Characterizing low-frequency artifacts during transcranial temporal interference stimulation (tTIS)

Jill von Conta,
Florian H. Kasten,
Branislava Ćurčić-Blake,
Klaus Schellhorn,
Christoph S. Herrmann

Affiliations

Jill von Conta: Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence “Hearing4All”, Carl von Ossietzky University, Oldenburg, Germany
Florian H. Kasten: Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence “Hearing4All”, Carl von Ossietzky University, Oldenburg, Germany; Neuroimaging Unit, European Medical School, Carl von Ossietzky University, Oldenburg, Germany
Branislava Ćurčić-Blake: Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
Klaus Schellhorn: neuroConn GmbH, Ilmenau, Germany
Christoph S. Herrmann: Experimental Psychology Lab, Department of Psychology, European Medical School, Cluster of Excellence “Hearing4All”, Carl von Ossietzky University, Oldenburg, Germany; Neuroimaging Unit, European Medical School, Carl von Ossietzky University, Oldenburg, Germany; Research Center Neurosensory Science, Carl von Ossietzky University, Oldenburg, Germany; Corresponding author. Experimental Psychology Lab, Carl von Ossietzky University, Ammerländer Heerstr. 114 – 118, 26129, Oldenburg, Germany.

Journal volume & issue: Vol. 2, no. 3
p. 100113

Abstract

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Transcranial alternating current stimulation (tACS) is a well-established brain stimulation technique to modulate human brain oscillations. However, due to the strong electro-magnetic artifacts induced by the stimulation current, the simultaneous measurement of tACS effects during neurophysiological recordings in humans is challenging. Recently, transcranial temporal interference stimulation (tTIS) has been introduced to stimulate neurons at depth non-invasively. During tTIS, two high-frequency sine waves are applied, that interfere inside the brain, resulting in amplitude modulated waveforms at the target frequency. Given appropriate hardware, we show that neurophysiological data during tTIS may be acquired without stimulation artifacts at low-frequencies. However, data must be inspected carefully for possible low-frequency artifacts. Our results may help to design experimental setups to record brain activity during tTIS, which may foster our understanding of its underlying mechanisms.

Published in Neuroimage: Reports

ISSN: 2666-9560 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage-reports

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