Phospholipase C delta 1 inhibits WNT/β‐catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma

Jianlian Xie; Jun Zhou; Jiliang Xia; Ying Zeng; Guo Huang; Weihong Zeng; Tingyu Fan; Lili Li; Xi Zeng; Qian Tao

doi:10.1186/s13148-023-01448-2

Clinical Epigenetics (Feb 2023)

Phospholipase C delta 1 inhibits WNT/β‐catenin and EGFR-FAK-ERK signaling and is disrupted by promoter CpG methylation in renal cell carcinoma

Jianlian Xie,
Jun Zhou,
Jiliang Xia,
Ying Zeng,
Guo Huang,
Weihong Zeng,
Tingyu Fan,
Lili Li,
Xi Zeng,
Qian Tao

Affiliations

Jianlian Xie: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Jun Zhou: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Jiliang Xia: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Ying Zeng: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Guo Huang: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Weihong Zeng: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Tingyu Fan: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Lili Li: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong
Xi Zeng: Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China
Qian Tao: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong

DOI: https://doi.org/10.1186/s13148-023-01448-2
Journal volume & issue: Vol. 15, no. 1
pp. 1 – 15

Abstract

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Highlights PLCD1 is methylated and downregulated in RCC and functions as a tumor suppressor gene Inactivation of PLCD1 contributes to RCC tumorigenesis. PLCD1 inhibits WNT/β-catenin and EGFR-FAK-ERK signaling in RCC.

Published in Clinical Epigenetics

ISSN: 1868-7083 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General): Genetics
Website: https://clinicalepigeneticsjournal.biomedcentral.com/

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Abstract

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