Nature Communications (Jan 2023)
Influence of circadian clocks on adaptive immunity and vaccination responses
- Louise Madeleine Ince,
- Coline Barnoud,
- Lydia Kay Lutes,
- Robert Pick,
- Chen Wang,
- Flore Sinturel,
- Chien-Sin Chen,
- Alba de Juan,
- Jasmin Weber,
- Stephan J. Holtkamp,
- Sophia Martina Hergenhan,
- Jennifer Geddes-McAlister,
- Stefan Ebner,
- Paola Fontannaz,
- Benjamin Meyer,
- Maria Vono,
- Stéphane Jemelin,
- Charna Dibner,
- Claire-Anne Siegrist,
- Felix Meissner,
- Frederik Graw,
- Christoph Scheiermann
Affiliations
- Louise Madeleine Ince
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Coline Barnoud
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Lydia Kay Lutes
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Robert Pick
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Chen Wang
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Flore Sinturel
- Department of Medicine, Division of Endocrinology, Diabetes, Nutrition and Patient Education, Faculty of Medicine, University of Geneva
- Chien-Sin Chen
- Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre
- Alba de Juan
- Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre
- Jasmin Weber
- Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre
- Stephan J. Holtkamp
- Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre
- Sophia Martina Hergenhan
- Walter-Brendel-Centre of Experimental Medicine, Ludwig-Maximilians-University Munich, BioMedical Centre
- Jennifer Geddes-McAlister
- Experimental Systems Immunology, Max Planck Institute of Biochemistry
- Stefan Ebner
- Experimental Systems Immunology, Max Planck Institute of Biochemistry
- Paola Fontannaz
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Benjamin Meyer
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Maria Vono
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Stéphane Jemelin
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Charna Dibner
- Department of Medicine, Division of Endocrinology, Diabetes, Nutrition and Patient Education, Faculty of Medicine, University of Geneva
- Claire-Anne Siegrist
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- Felix Meissner
- Experimental Systems Immunology, Max Planck Institute of Biochemistry
- Frederik Graw
- BioQuant - Center for Quantitative Biology, Heidelberg University
- Christoph Scheiermann
- Department of Pathology and Immunology, Faculty of Medicine, University of Geneva
- DOI
- https://doi.org/10.1038/s41467-023-35979-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Circadian rhythms have been shown to influence immune responses, but it is unclear whether this influences responses to vaccines. Here the authors show that dendritic cells migrate in a circadian rhythm meaning that interactions with T cells are altered leading to differential vaccine responses.
