npj Microgravity (Oct 2023)

How do gravity alterations affect animal and human systems at a cellular/tissue level?

  • Francesca Cialdai,
  • Austin M. Brown,
  • Cory W. Baumann,
  • Debora Angeloni,
  • Sarah Baatout,
  • Alexandra Benchoua,
  • Juergen Bereiter-Hahn,
  • Daniele Bottai,
  • Judith-Irina Buchheim,
  • Marco Calvaruso,
  • Eugénie Carnero-Diaz,
  • Sara Castiglioni,
  • Duccio Cavalieri,
  • Gabriele Ceccarelli,
  • Alexander Choukér,
  • Gianni Ciofani,
  • Giuseppe Coppola,
  • Gabriella Cusella,
  • Andrea Degl’Innocenti,
  • Jean-Francois Desaphy,
  • Jean-Pol Frippiat,
  • Michael Gelinsky,
  • Giada Genchi,
  • Maria Grano,
  • Daniela Grimm,
  • Alain Guignandon,
  • Christiane Hahn,
  • Jason Hatton,
  • Raúl Herranz,
  • Christine E. Hellweg,
  • Carlo Saverio Iorio,
  • Thodoris Karapantsios,
  • Jack van Loon,
  • Matteo Lulli,
  • Jeanette Maier,
  • Jos Malda,
  • Emina Mamaca,
  • Lucia Morbidelli,
  • Angelique van Ombergen,
  • Andreas Osterman,
  • Aleksandr Ovsianikov,
  • Francesco Pampaloni,
  • Elizabeth Pavezlorie,
  • Veronica Pereda-Campos,
  • Cyrille Przybyla,
  • Christopher Puhl,
  • Petra Rettberg,
  • Chiara Risaliti,
  • Angela Maria Rizzo,
  • Kate Robson-Brown,
  • Leonardo Rossi,
  • Giorgio Russo,
  • Alessandra Salvetti,
  • Daniela Santucci,
  • Matthias Sperl,
  • Felice Strollo,
  • Kevin Tabury,
  • Sara Tavella,
  • Christiane Thielemann,
  • Ronnie Willaert,
  • Nathaniel J. Szewczyk,
  • Monica Monici

Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9


Read online

Abstract The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.