Impact of Obesity on Breast Cancer

Abstract

Background: Obesity is linked with a high risk of breast cancer and affects prognosis as it is correlated with different molecular subtypes. Method: All breast cancer patients referred to Kasr Alainy Oncology Center of Clinical Oncology and Nuclear Medicine (NEMROCK) from 2004 to2014 were recruited in this retrospective study. They were divided into three groups according to body mass index (BMI): non-obese (BMI 30 had a worse mean overall survival (OS) (80, 88, and 102.5 months in obese, severely obese, and non-obese patients, respectively, P=0.019); however, this did not affect the disease-free survival (P = 0.40). In multivariate analysis, the factors that also had a significant effect on OS were lymph node stage (P 35) had a poor OS with no influence on disease-free survival.

Keywords

• body mass index
• obesity
• breast cancer
• prognostic factors
• overall survival