Nature Communications (Mar 2023)
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals
- Arnaud Landra-Willm,
- Ameya Karapurkar,
- Alexia Duveau,
- Anne Amandine Chassot,
- Lucille Esnault,
- Gerard Callejo,
- Marion Bied,
- Stephanie Häfner,
- Florian Lesage,
- Brigitte Wdziekonski,
- Anne Baron,
- Pascal Fossat,
- Laurent Marsollier,
- Xavier Gasull,
- Eric Boué-Grabot,
- Michael A. Kienzler,
- Guillaume Sandoz
Affiliations
- Arnaud Landra-Willm
- Université Côte d’Azur, CNRS, INSERM, iBV
- Ameya Karapurkar
- University of Maine Department of Chemistry
- Alexia Duveau
- Univ. Bordeaux, CNRS, IMN, UMR 5293
- Anne Amandine Chassot
- Université Côte d’Azur, CNRS, INSERM, iBV
- Lucille Esnault
- Univ Angers, Nantes Université, INSERM, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302
- Gerard Callejo
- Neurophysiology Laboratory, Department of Biomedicine, Medical School, Institute of Neurosciences, Universitat de Barcelona
- Marion Bied
- Université Côte d’Azur, CNRS, INSERM, iBV
- Stephanie Häfner
- Université Côte d’Azur, CNRS, INSERM, iBV
- Florian Lesage
- Laboratories of Excellence, Ion Channel Science and Therapeutics
- Brigitte Wdziekonski
- Université Côte d’Azur, CNRS, INSERM, iBV
- Anne Baron
- Laboratories of Excellence, Ion Channel Science and Therapeutics
- Pascal Fossat
- Univ. Bordeaux, CNRS, IMN, UMR 5293
- Laurent Marsollier
- Univ Angers, Nantes Université, INSERM, Immunology and New Concepts in ImmunoTherapy, INCIT, UMR 1302
- Xavier Gasull
- Neurophysiology Laboratory, Department of Biomedicine, Medical School, Institute of Neurosciences, Universitat de Barcelona
- Eric Boué-Grabot
- Univ. Bordeaux, CNRS, IMN, UMR 5293
- Michael A. Kienzler
- University of Connecticut Department of Chemistry
- Guillaume Sandoz
- Université Côte d’Azur, CNRS, INSERM, iBV
- DOI
- https://doi.org/10.1038/s41467-023-36806-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
Research on pain often relies on animals, and there is always a need for more precise and more ethical tools. Here, authors present a light-activatable molecule that induces pain in freely moving animal models in a reversible, non-invasive, and spatiotemporally defined way.
