Scientific Reports (Jul 2022)
Presence of specific SARS-COV2 antibodies in hemodialysis patients and their caregivers after the first wave of COVID-19
- Thomas Robert,
- Guillaume Lano,
- Noémie Resseguier,
- Mickaël Bobot,
- Dammar Bouchouareb,
- Stéphane Burtey,
- Xavier de Lamballerie,
- Jean Dhorne,
- Bertrand Dussol,
- Ariane Duval,
- Julien Faraut,
- Toscane Fourié,
- Philippe Giaime,
- Mourad Hallah,
- Dominique Jaubert,
- Océane Jéhel,
- Tristan Legris,
- Stéphane Liotatis,
- Valérie Moal,
- Laetitia Ninove,
- Nathalie Pedinielli,
- Marion Pelletier,
- Manon Romeu-Giannoli,
- Mariela Saba,
- Marion Sallée,
- Laurent Samson,
- Adriana Saveanu,
- Violaine Scarfoglière,
- Pascale Sebahoun,
- Romain Vial,
- Clarissa Von Kotze,
- Philippe Brunet,
- Gaëtan Lebrun,
- Stanislas Bataille,
- Noémie Jourde-Chiche
Affiliations
- Thomas Robert
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Guillaume Lano
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Noémie Resseguier
- Laboratoire de Santé Publique, CERESS, Aix-Marseille Université
- Mickaël Bobot
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Dammar Bouchouareb
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Stéphane Burtey
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Xavier de Lamballerie
- Unité des Virus Émergents, IRD 190, Inserm 1207, Aix-Marseille Université
- Jean Dhorne
- AP-HM, Direction de la Recherche Santé
- Bertrand Dussol
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Ariane Duval
- Association des Dialysés de Provence et Corse (ADPC)
- Julien Faraut
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Toscane Fourié
- Unité des Virus Émergents, IRD 190, Inserm 1207, Aix-Marseille Université
- Philippe Giaime
- Institut Phocéen de Néphrologie, Clinique Bouchard
- Mourad Hallah
- Service de Néphrologie et Hémodialyse, Centre Hospitalier Intercommunal Aix-Pertuis (CHIAP)
- Dominique Jaubert
- Service de Néphrologie et Hémodialyse, Centre Hospitalier Intercommunal Aix-Pertuis (CHIAP)
- Océane Jéhel
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Tristan Legris
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Stéphane Liotatis
- AP-HM, Direction de la Recherche Santé
- Valérie Moal
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Laetitia Ninove
- Unité des Virus Émergents, IRD 190, Inserm 1207, Aix-Marseille Université
- Nathalie Pedinielli
- Institut Phocéen de Néphrologie, Clinique Bouchard
- Marion Pelletier
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Manon Romeu-Giannoli
- Association des Dialysés de Provence et Corse (ADPC)
- Mariela Saba
- Unité des Virus Émergents, IRD 190, Inserm 1207, Aix-Marseille Université
- Marion Sallée
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Laurent Samson
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Adriana Saveanu
- Association des Dialysés de Provence et Corse (ADPC)
- Violaine Scarfoglière
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Pascale Sebahoun
- Association des Dialysés de Provence et Corse (ADPC)
- Romain Vial
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Clarissa Von Kotze
- Association des Dialysés de Provence et Corse (ADPC)
- Philippe Brunet
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- Gaëtan Lebrun
- Service de Néphrologie et Hémodialyse, Centre Hospitalier Intercommunal Aix-Pertuis (CHIAP)
- Stanislas Bataille
- INSERM, INRAe, C2VN, Aix-Marseille Université
- Noémie Jourde-Chiche
- AP-HM, CHU Conception, Centre de Néphrologie et Transplantation Rénale
- DOI
- https://doi.org/10.1038/s41598-022-15913-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
Abstract Hemodialysis (HD) patients are at risk for severe COVID-19 and cannot comply with social distancing. SARS-COV2 seroprevalence in French patients and caregivers after the first wave of COVID-19 is unknown. SeroCOVIDial is a prospective study conducted between June and December 2020. SARS-COV2 seroprevalence was evaluated by a rapid serological test (BIOSYNEX) in HD patients and caregivers, and the presence or not of anti-SARS-COV2 neutralizing or non-neutralizing antibodies in patients was also determined by ELISA and seroneutralization. In June 2020, 451 HD patients and 238 caregivers were included. Overall SARS-COV2 seroprevalence was 8.4% (patients) and 6.7% (caregivers), and was 87.1% (patients) and 90.0% (caregivers) in participants with a previously documented SARS-COV2 infection. Overall seroprevalence reached 13.8% (patients) and 12.6% (caregivers) following the second epidemic wave. During the follow-up, 38 (8.4%) patients died (9 of COVID-19). Among the 44 (10.6%) patients who became infected, only two were seropositive at M0. The levels of anti-SARS-COV2 antibodies decreased over time in patients and caregivers. The BIOSYNEX test showed 82.9% sensitivity and 97.7% specificity. Prevalence of anti-SARS-COV2 antibodies was low in HD patients and caregivers after the first epidemic wave but rose after the second wave. A rapid serological test showed good performances and could be useful for future monitoring of anti-SARS-COV2 antibodies.
