Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B

Chan Yul Yoo; Jiangman He; Qing Sang; Yongjian Qiu; Lingyun Long; Ruth Jean-Ae Kim; Emily G. Chong; Joseph Hahm; Nicholas Morffy; Pei Zhou; Lucia C. Strader; Akira Nagatani; Beixin Mo; Xuemei Chen; Meng Chen

doi:10.1038/s41467-021-25909-5

Nature Communications (Sep 2021)

Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B

Chan Yul Yoo,
Jiangman He,
Qing Sang,
Yongjian Qiu,
Lingyun Long,
Ruth Jean-Ae Kim,
Emily G. Chong,
Joseph Hahm,
Nicholas Morffy,
Pei Zhou,
Lucia C. Strader,
Akira Nagatani,
Beixin Mo,
Xuemei Chen,
Meng Chen

Affiliations

Chan Yul Yoo: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Jiangman He: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Qing Sang: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Yongjian Qiu: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Lingyun Long: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Ruth Jean-Ae Kim: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Emily G. Chong: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Joseph Hahm: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Nicholas Morffy: Department of Biology, Duke University
Pei Zhou: Department of Biochemistry, Duke University School of Medicine
Lucia C. Strader: Department of Biology, Duke University
Akira Nagatani: Department of Botany, Graduate School of Science, Kyoto University
Beixin Mo: Guangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University
Xuemei Chen: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California
Meng Chen: Department of Botany and Plant Sciences, Institute for Integrative Genome Biology, University of California

DOI: https://doi.org/10.1038/s41467-021-25909-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Photoactivated phytochrome B regulates gene expression by interacting with PIF transcription factors. Here the authors show that PIF3 contains a p53-like transcription activation domain (AD) and that PHYB can directly suppress PIF3 transactivation activity by binding adjacent to the AD.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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