Nature Communications (Jan 2017)

KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling

  • Kenneth B. Schou,
  • Johanne B. Mogensen,
  • Stine K. Morthorst,
  • Brian S. Nielsen,
  • Aiste Aleliunaite,
  • Andrea Serra-Marques,
  • Nicoline Fürstenberg,
  • Sophie Saunier,
  • Albane A. Bizet,
  • Iben R. Veland,
  • Anna Akhmanova,
  • Søren T. Christensen,
  • Lotte B. Pedersen

DOI
https://doi.org/10.1038/ncomms14177
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

The ciliary transition zone (TZ) regulates the protein and membrane composition of the primary cilium. Here the authors identify the kinesin-3 motor protein KIF13B as a regulator of TZ membrane composition that controls the ciliary accumulation of Smoothened, which is involved in activation of Sonic hedgehog signalling.