1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

Michaela Schedel; Yi Jia; Sven Michel; Katsuyuki Takeda; Joanne Domenico; Anthony Joetham; Fangkun Ning; Matthew Strand; Junyan Han; Meiqin Wang; Joseph J. Lucas; Christian Vogelberg; Michael Kabesch; Brian P. O’Connor; Erwin W. Gelfand

doi:10.1038/ncomms10213

Nature Communications (Jan 2016)

1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter

Michaela Schedel,
Yi Jia,
Sven Michel,
Katsuyuki Takeda,
Joanne Domenico,
Anthony Joetham,
Fangkun Ning,
Matthew Strand,
Junyan Han,
Meiqin Wang,
Joseph J. Lucas,
Christian Vogelberg,
Michael Kabesch,
Brian P. O’Connor,
Erwin W. Gelfand

Affiliations

Michaela Schedel: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Yi Jia: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Sven Michel: Department of Pediatric Pneumology and Allergy, University Children’s Hospital Regensburg (KUNO)
Katsuyuki Takeda: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Joanne Domenico: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Anthony Joetham: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Fangkun Ning: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Matthew Strand: Division of Biostatistics and Bioinformatics, National Jewish Health
Junyan Han: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Meiqin Wang: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Joseph J. Lucas: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Christian Vogelberg: Department of Pediatrics, University Children’s Hospital, Technical University
Michael Kabesch: Department of Pediatric Pneumology and Allergy, University Children’s Hospital Regensburg (KUNO)
Brian P. O’Connor: Division of Cell Biology, Department of Pediatrics, National Jewish Health
Erwin W. Gelfand: Division of Cell Biology, Department of Pediatrics, National Jewish Health

DOI: https://doi.org/10.1038/ncomms10213
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Type 2 CD8+ T cells (Tc2) play a role in the development of experimental asthma. Here the authors show that 1,25D3, the active form of vitamin D3, can prevent conversion of CD8+T cells to a Tc2 phenotype, reducing asthma susceptibility.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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