Nature Communications (Feb 2021)

Loop competition and extrusion model predicts CTCF interaction specificity

  • Wang Xi,
  • Michael A. Beer

DOI
https://doi.org/10.1038/s41467-021-21368-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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Boundaries of topologically associated domains in genomes are marked by CTCF and cohesin binding. Here the authors predict CTCF interaction specificity by building a simple mathematical model with features including loop competition and extrusion.