A diastereoselective approach to axially chiral biaryls via electrochemically enabled cyclization cascade

Abstract

A diastereoselective approach to axially chiral imidazopyridine-containing biaryls has been developed. The reactions proceed through a radical cyclization cascade to construct the biaryls with good to excellent central-to-axial chirality transfer.

Keywords

• axial chirality
• biaryl
• electrochemistry
• oxidation
• radical