Nature Communications (Mar 2019)

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair

  • Wenting Yang,
  • Yuandong Tao,
  • Yan Wu,
  • Xinyuan Zhao,
  • Weijie Ye,
  • Dianyuan Zhao,
  • Ling Fu,
  • Caiping Tian,
  • Jing Yang,
  • Fuchu He,
  • Li Tang

DOI
https://doi.org/10.1038/s41467-019-09046-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Neutrophils and macrophages are both involved in the initiation of inflammation, but whether and how they may participate in inflammation resolution is unclear. Here the authors show that neutrophils may mediate the conversion of macrophage into a pro-resolution phenotype via reactive oxygen species production to promote liver repair.