Journal of Pain Research (Aug 2024)
Effects of Transverse Abdominis Plane (TAP) Block on the MACBAR of Sevoflurane in Gynecologic Patients with Laparoscopic Pneumoperitoneal Stimulation: An Up-Down Sequential Allocation Study
Abstract
PingPing Jiang,1,* JingTao Tang,2,* Min Zhang,3 Dan Wang1 1Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 2Department of Anesthesia, The Second People’s hospital of Neijiang, Neijiang, Sichuan, People’s Republic of China; 3Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: PingPing Jiang, Department of Anesthesia, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, People’s Republic of China, Tel +86 15881496034, Email [email protected]: This study aimed to observe the effect of bilateral transverse abdominis plane (TAP) block on the MACBAR of sevoflurane in gynecological patients with laparoscopic pneumoperitoneal stimulation.Patients and Methods: Fifty patients who underwent laparoscopic surgery were randomly assigned to either the control group (n= 25) or the TAP block group (n= 25). Patients in the TAP block group were subjected to a bilateral transversal abdominal muscle plane block with 0.33% ropivacaine (20 mL on each side) guided by ultrasound. The control group received an equal volume of normal saline. The MACBAR of sevoflurane in each group was determined using a sequential allocation technique.Results: The MACBAR of sevoflurane in the TAP block group was significantly lower than that in the control group (4.20% [95% confidence interval {CI}, 4.02%– 4.38%] vs 5.03% [95% CI, 4.89%– 5.18%]).Conclusion: Bilateral TAP block can reduce the MACBAR of sevoflurane in gynecological patients with pneumoperitoneum stimulation.Trial Registration Number: ChiCTR2100046517. The trial is publicly available and registered at www.chictr.org.cn on May 18, 2021.Keywords: Transverse abdominis plane block, Adrenergic response, Minimum alveolar concentration, Pneumoperitoneum stimulation, Sevoflurane
