Sedoanalgesia with midazolam-ketamine in the mechanically ventilated critically ill patient

Abstract

The sedoanalgesia is recommended for patients under artificial mechanical ventilation in order to achieve better patient satisfaction and to prevent complications. The objective of this work was to carry out a literature review about the sedoanalgesic effect to the combination of midazolam-morphine compared with comidazolam-ketamine in critically ill patients treated with artificial mechanical ventilation. A manual and digital search was carried out in different databases such as Scielo, IBECS, MEDLINE, Google Scholar, Cochrane, and Wh, using the following descriptors in English: sedation, midazolam-ketamine, midazolam-morphine, AND mechanical ventilation AND critical illness (MeSH terms). We found 60 articles, all of which reported human-related cases, 32 in the last 5 years, but only 16 at full text. Out of these, seven were systematic reviews about the subject and only four, clinical trials. We did not find any articles in the review that reported about the advantages of the association midazolam-ketamine in sedation of mechanically ventilated critically ill patients, a fact that confers novelty to the investigation.

Keywords

• sedación
• midazolam-ketamina
• midazolam-morfina
• ventilación mecánica
• pacientes críticos