Human islets contain four distinct subtypes of β cells

Craig Dorrell; Jonathan Schug; Pamela S. Canaday; Holger A. Russ; Branden D. Tarlow; Maria T. Grompe; Tamara Horton; Matthias Hebrok; Philip R. Streeter; Klaus H. Kaestner; Markus Grompe

doi:10.1038/ncomms11756

Nature Communications (Jul 2016)

Human islets contain four distinct subtypes of β cells

Craig Dorrell,
Jonathan Schug,
Pamela S. Canaday,
Holger A. Russ,
Branden D. Tarlow,
Maria T. Grompe,
Tamara Horton,
Matthias Hebrok,
Philip R. Streeter,
Klaus H. Kaestner,
Markus Grompe

Affiliations

Craig Dorrell: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road
Jonathan Schug: Department of Genetics and Institute for Diabetes, Obesity, and Metabolism; University of Pennsylvania School of Medicine
Pamela S. Canaday: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road
Holger A. Russ: Department of Medicine, Diabetes Center, University of California San Francisco
Branden D. Tarlow: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road
Maria T. Grompe: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road
Tamara Horton: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road
Matthias Hebrok: Department of Medicine, Diabetes Center, University of California San Francisco
Philip R. Streeter: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road
Klaus H. Kaestner: Department of Genetics and Institute for Diabetes, Obesity, and Metabolism; University of Pennsylvania School of Medicine
Markus Grompe: Department of Pediatrics, Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road

DOI: https://doi.org/10.1038/ncomms11756
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 9

Abstract

Read online

Dysfunction or loss of insulin-secreting β cells in the pancreas is a hallmark of diabetes. Here, Dorrell et al.identify four subpopulations of β cells in humans, which differ in gene expression and insulin secretion kinetics, and the abundance of which is altered in patients with type 2 diabetes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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