Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules

Abstract

A review of the synthesis of natural products and bioactive compounds adopting phosphonamide anion technology is presented highlighting the utility of phosphonamide reagents in stereocontrolled bond-forming reactions. Methodologies utilizing phosphonamide anions in asymmetric alkylations, Michael additions, olefinations, and cyclopropanations will be summarized, as well as an overview of the synthesis of the employed phosphonamide reagents.

Keywords

• conjugate addition
• cyclopropanation
• olefination
• organophosphorus
• phosphonamide
• total synthesis