Prevalence and Trends of Transfusion-Transmissible HBV Infection Among Blood Donors in Southwestern China: A Six-Year Retrospective Study

Abstract

Qiaolin Zhang,1,* Zhu Mei,2,* Lan Wei,1 Dong Liu,1 Chengbing Xie,1 Yongzhu Xu1 1Department of Clinical Laboratory, Chongqing Blood Center, Chongqing, People’s Republic of China; 2Department of Clinical Laboratory, The First People’s Hospital of Chongqing Liangjiang New Area, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yongzhu Xu, Department of Clinical Laboratory, Chongqing Blood Center, Chongqing, People’s Republic of China, Email [email protected]: Hepatitis B virus (HBV) infection is a significant global public health concern, with variable prevalence rates across regions. The prevalence of transfusion-transmitted HBV infection (TT-HBV) via donated blood necessitates an evaluation of blood safety and potential risks to the population. This study assessed the prevalence of HBV infection among blood donors in Southwestern China over 6 years.Methods: We analyzed 903,023 blood donations from a central blood center in Southwestern China between January 2017 and December 2022. The prevalence of HBV in donations was determined for one-time and repeat donors, considering birth cohorts and covariates. Demographic characteristics, donation frequency, and anti-HBV antibody status were analyzed to estimate the incidence of TT-HBV.Results: One-time donors provided 47.78% of the samples, and 52.22% were from repeat donors. The HBV prevalence decreased from 1.0% in 2017 to 0.87% in 2022 in one-time donors and from 0.30% to 0.09%, respectively, in repeat donors. A significantly lower HBV prevalence was identified in the post-1992 birth cohort (0.33%) than in the pre-1992 birth cohort (1.67%). The estimated incidences of TT-HBV occurring from one-time donors, repeat donors, post-1992 birth cohort donors, and pre-1992 birth cohort donors were 20.76, 13.84, 0.82, and 20.98 per 104 person-years, respectively.Conclusion: Our findings indicate a decreasing trend in HBV prevalence among blood donors in Southwestern China over the 6-year study period. This decline may be attributed to the widespread administration of HBV vaccinations and stringent screening measures implemented by blood donation centers. Continuous monitoring for HBV among blood donors is necessary to evaluate the effectiveness of preventive measures and inform future strategies to reduce transmission.Keywords: hepatitis B virus, transfusion-transmitted infections, epidemiology, vaccination

Keywords

• hepatitis b virus
• transfusion-transmitted infections
• epidemiology
• vaccination