Nature Communications (Jan 2016)
Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis
- Shrikant R. Mulay,
- Jyaysi Desai,
- Santhosh V. Kumar,
- Jonathan N. Eberhard,
- Dana Thomasova,
- Simone Romoli,
- Melissa Grigorescu,
- Onkar P. Kulkarni,
- Bastian Popper,
- Volker Vielhauer,
- Gabriele Zuchtriegel,
- Christoph Reichel,
- Jan Hinrich Bräsen,
- Paola Romagnani,
- Rostyslav Bilyy,
- Luis E. Munoz,
- Martin Herrmann,
- Helen Liapis,
- Stefan Krautwald,
- Andreas Linkermann,
- Hans-Joachim Anders
Affiliations
- Shrikant R. Mulay
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Jyaysi Desai
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Santhosh V. Kumar
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Jonathan N. Eberhard
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Dana Thomasova
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Simone Romoli
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Melissa Grigorescu
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Onkar P. Kulkarni
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Bastian Popper
- Department of Anatomy and Cell Biology, Ludwig-Maximilians Universität
- Volker Vielhauer
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- Gabriele Zuchtriegel
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich
- Christoph Reichel
- Department of Otorhinolaryngology, Head and Neck Surgery, University of Munich
- Jan Hinrich Bräsen
- Department of Nephropathology, Institute for Pathology, Hannover Medical School
- Paola Romagnani
- Excellence Centre for Research, Transfer and High Education for the Development of De Novo Therapies (DENOTHE), University of Florence
- Rostyslav Bilyy
- Danylo Halytsky Lviv National Medical University
- Luis E. Munoz
- Department for Internal Medicine, University Hospital Erlangen, Institute for Clinical Immunology
- Martin Herrmann
- Department for Internal Medicine, University Hospital Erlangen, Institute for Clinical Immunology
- Helen Liapis
- Department of Pathology and Immunology, Washington University School of Medicine
- Stefan Krautwald
- Division of Nephrology and Hypertension, Christian-Albrechts-University
- Andreas Linkermann
- Division of Nephrology and Hypertension, Christian-Albrechts-University
- Hans-Joachim Anders
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität
- DOI
- https://doi.org/10.1038/ncomms10274
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Kidney stone disease is caused by accumulation of oxalate crystals, which trigger tissue injury, inflammation and cell death. Mulay et al. show that crystals induce cell death in the kidney through necroptosis, and propose that this pathway may be a target for the treatment of crystal-induced disease.
