Impact of Vitamin E Supplementation on Blood Pressure and Hs-CRP in Type 2 Diabetic Patients

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a major public health problem worldwide.Hypertension and inflammation are well recognized as risk factors for the macrovascular complicationsof diabetes. The aim of this study was to assess the impact of vitamin E supplementationon blood pressure (BP), serum high-sensitivity C-reactive protein (hs-CRP) and fasting bloodglucose in patients with T2DM.Methods: In a double blind, randomized, controlled clinical trial, 83 patients with T2DM weredivided randomly into two groups of vitamin E (400 mg/d, n=42) and placebo (n=41). All patientsreceived the pearls for 8 weeks. Baseline and eighth week BP, serum hs-CRP, fasting bloodglucose, anthropometric and dietary intake data were obtained from each patient. Data were analyzedusing SPSS version 11.5.Results: Vitamin E supplementation significantly increased serum levels of vitamin E (P <0.001) and decreased mean arterial pressure and fasting blood glucose (P = 0.047, P = 0.028, respectively)in vitamin E group as compared with placebo group. A significant decrease in systolicblood pressure and diastolic blood pressure was observed in the vitamin E group comparing withbaseline values (all P < 0.01). There were no significant changes in serum hs-CRP in both of thestudied groups.Conclusion: Vitamin E had beneficial effects on serum vitamin E, BP and blood glucose in patientswith T2DM. Improvement in BP and glucose control may contribute to reducing complicationsof diabetes including cardiovascular risk in these patients.

Keywords

• Vitamin E
• Blood pressure
• Inflammation
• Type 2 diabetes