miR-137: A Novel Therapeutic Target for Human Glioma

Yajun Wang; Riling Chen; Xia Zhou; Runmin Guo; Jingwen Yin; You Li; Guoda Ma

doi:10.1016/j.omtn.2020.06.028

Molecular Therapy: Nucleic Acids (Sep 2020)

miR-137: A Novel Therapeutic Target for Human Glioma

Yajun Wang,
Riling Chen,
Xia Zhou,
Runmin Guo,
Jingwen Yin,
You Li,
Guoda Ma

Affiliations

Yajun Wang: Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China; Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK
Riling Chen: Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China
Xia Zhou: Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
Runmin Guo: Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China
Jingwen Yin: Department of Psychiatry, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
You Li: Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China; Corresponding author: You Li, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Guoda Ma: Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China; Corresponding author: Guoda Ma, Maternal and Children’s Health Research Institute, Shunde Women and Children’s Hospital, Guangdong Medical University, Foshan 528300, China.

DOI: https://doi.org/10.1016/j.omtn.2020.06.028
Journal volume & issue: Vol. 21
pp. 614 – 622

Abstract

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MicroRNA (miR)-137 is highly expressed in the brain and plays a crucial role in the development and prognosis of glioma. In this review, we aim to summarize the latest findings regarding miR-137 in glioma cell apoptosis, proliferation, migration, invasion, angiogenesis, drug resistance, and cancer treatment. In addition, we focus on the identified miR-137 targets and pathways in the occurrence and development of glioma. Finally, future implications for the diagnostic and therapeutic potential of miR-137 in glioma were discussed.

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

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