mBio (Feb 2021)

Structural Characterization of Diazabicyclooctane β-Lactam “Enhancers” in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa

  • Malligarjunan Rajavel,
  • Vijay Kumar,
  • Ha Nguyen,
  • Jacob Wyatt,
  • Steven H. Marshall,
  • Krisztina M. Papp-Wallace,
  • Prasad Deshpande,
  • Satish Bhavsar,
  • Ravindra Yeole,
  • Sachin Bhagwat,
  • Mahesh Patel,
  • Robert A. Bonomo,
  • Focco van den Akker

DOI
https://doi.org/10.1128/mBio.03058-20
Journal volume & issue
Vol. 12, no. 1

Abstract

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Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.