INVESTIGATION OF THE FEATURES OF THE GENETIC STRUCTURE OF INDIGENOUS POPULATION IN SOUTHERN SIBERIA IN THE CONTEXT OF EXPOSURE TO CARDIOVASCULAR SYSTEM DISEASES

Abstract

The paper presents the results of studies of the genetic structure of the population of 11 indigenous peoples of southernSiberiaaccording to autosomal DNA markers. The survey covers the populations of the peoples of the Altai (Altai-Kizhi, Kumandins, Tubalars, Telengits, Chelkans), Khakassia (Kachin, Koybaly, Kyzyltsy, Sagaytsy, Shors Abakan), Mountain Shoria (Mountain-Taiga Shors). The total volume of samples of the indigenous peoples included in this study amounted 1058 people. Genotyping of samples was carried out by a single spectrum of genetic markers: Alu-polymorphism in the genes ACE, PLAT, ApoA1, CDH13, F13B. It demonstrated the specificity of the genetic structure of the populations of Southern Siberian due to the study of complex genes. The maximum genetic distancing from all the peoples ofSouthern Siberiapopulation was noted in theShorsof the mountain-taiga zone of Kemerovo region (0.03) and the Kumandins of the Altai region (0.05). Meanwhile, the Shors revealed high values of Alu-insertions frequency in the genes ACE and PLAT, at low values of insertions in the genes of ApoA1, CDH13, F13B. Kumandins have low frequencies of Alu-insertions in the genes ACE, PLAT, F13B

Keywords

• genetic markers, disease, cardiovascular system, indigenous peoples, population, southern siberia