Effect of pre-operative internal obturator muscle mass index in MRI on biochemical recurrence of prostate cancer patients after radical prostatectomy: a multi-center study
Won Tae Kim,
Ho Won Kang,
Sung Pil Seo,
Yong-June Kim,
Sang Cheol Lee,
Wun-Jae Kim,
Bum Sang Cho,
Yun Sok Ha,
Tae Gyun Kwon,
Jinsung Park,
Seung Chol Park,
Young Beom Jeong,
Taek Won Kang,
Sung-Woo Park,
Seok Joong Yun
Affiliations
Won Tae Kim
Department of Urology, College of Medicine, Chungbuk National University
Ho Won Kang
Department of Urology, College of Medicine, Chungbuk National University
Sung Pil Seo
Department of Urology, Chungbuk National University Hospital
Yong-June Kim
Department of Urology, College of Medicine, Chungbuk National University
Sang Cheol Lee
Department of Urology, College of Medicine, Chungbuk National University
Wun-Jae Kim
Department of Urology, College of Medicine, Chungbuk National University
Bum Sang Cho
Department of Radiology, College of Medicine, Chungbuk National University
Yun Sok Ha
Department of Urology, College of Medicine, Kyungpook National University
Tae Gyun Kwon
Department of Urology, College of Medicine, Kyungpook National University
Jinsung Park
Department of Urology, College of Medicine, Eulji University
Seung Chol Park
Department of Urology, College of Medicine, Won Kang University
Young Beom Jeong
Department of Urology, College of Medicine, Jeonbuk National University
Taek Won Kang
Department of Urology, College of Medicine, Jeonnam National University
Sung-Woo Park
Department of Urology, College of Medicine, Pusan National University
Seok Joong Yun
Department of Urology, College of Medicine, Chungbuk National University
Abstract Background Recent reports show that the pre-operative or post-operative skeletal mass index (sarcopenia) affects survival rates for various cancers; however, the link between prostate cancer survival and sarcopenia is unclear. Therefore, this study examined the effect of the pre-operative internal obturator muscle (IOM) mass index on biochemical recurrence (BCR) of prostate cancer (PCa) patients who underwent radical prostatectomy. Methods In total, 222 patients, who underwent open, laparoscopic, or robot-assisted radical prostatectomy at seven centers in 2011 and were followed up for 5 years, were enrolled. BCR was examined in the context of pre-operative IOM mass index and BMI. Results The mean age of the patients was 67.82 ± 6.23 years, and the mean pre-operative prostate-specific antigen (PSA) level was 11.61 ± 13.22 ng/ml. There was no significant difference in baseline characteristics between the low and high IOM mass index groups (p > 0.05). Age, pre-op PSA level, ECE, and T-stage were associated with BCR (p = 0.049, p 0.05). Conclusions Pre-operative IOM mass index was not associated with BCR; however, long-term follow-up is necessary to evaluate cancer-specific and overall survival of PCa patients.
