Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism

Marc M. Dwenger; Sean M. Raph; Michelle L. Reyzer; M. Lisa Manier; Daniel W. Riggs; Zachary B. Wohl; Vahagn Ohanyan; Gregory Mack,; Thomas Pucci; Joseph B. Moore; Bradford G. Hill; William M. Chilian; Richard M. Caprioli; Aruni Bhatnagar; Matthew A. Nystoriak

doi:10.1038/s41467-022-29745-z

Nature Communications (Apr 2022)

Pyridine nucleotide redox potential in coronary smooth muscle couples myocardial blood flow to cardiac metabolism

Marc M. Dwenger,
Sean M. Raph,
Michelle L. Reyzer,
M. Lisa Manier,
Daniel W. Riggs,
Zachary B. Wohl,
Vahagn Ohanyan,
Gregory Mack,,
Thomas Pucci,
Joseph B. Moore,
Bradford G. Hill,
William M. Chilian,
Richard M. Caprioli,
Aruni Bhatnagar,
Matthew A. Nystoriak

Affiliations

Marc M. Dwenger: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
Sean M. Raph: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
Michelle L. Reyzer: Department of Biochemistry, Vanderbilt University School of Medicine
M. Lisa Manier: Department of Biochemistry, Vanderbilt University School of Medicine
Daniel W. Riggs: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
Zachary B. Wohl: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
Vahagn Ohanyan: Department of Integrative Medical Sciences, Northeast Ohio Medical University
Gregory Mack,: Department of Integrative Medical Sciences, Northeast Ohio Medical University
Thomas Pucci: Department of Integrative Medical Sciences, Northeast Ohio Medical University
Joseph B. Moore: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
Bradford G. Hill: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
William M. Chilian: Department of Integrative Medical Sciences, Northeast Ohio Medical University
Richard M. Caprioli: Department of Biochemistry, Vanderbilt University School of Medicine
Aruni Bhatnagar: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville
Matthew A. Nystoriak: Department of Medicine, Division of Environmental Medicine, Diabetes and Obesity Center, University of Louisville

DOI: https://doi.org/10.1038/s41467-022-29745-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Physiological matching of blood flow to the demand for oxygen by the heart is required for sustained cardiac health, yet the underlying mechanisms are obscure. Here, the authors report a key role for acute modifications to the redox state of intracellular pyridine nucleotides in coronary smooth muscle and their impact on voltage-gated K + channels in metabolic vasodilation

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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