Radiological and morphological parallels in the course of respiratory sarcoidosis

Abstract

The objective of the study: to study the radiological and morphological parallels in respiratory sarcoidosis (RS).Subjects and methods. 121 patients with respiratory sarcoidosis were enrolled in the study, their ages varied from 21 to 66 years, they all were examined in 2007-2019. The analysis of radiological manifestations of sarcoidosis was assessed according to the main parameters (symmetry of the lesions, the size of the intrathoracic lymph nodes, the presence of dissemination, pneumofibrosis). The extended morphological testing of biopsy specimens was carried including evaluation of the quantitative and qualitative composition of granulomas.Results. The chest computed tomography revealed a discrepancy between the radiation signs in respiratory sarcoidosis and the staging theory by Wurm. Changes in the lung parenchyma and swelling of the mediastinal lymph nodes were found in all patients at stages I-III. The components of the cellular elements of the inflammatory infiltrate did not differ at different stages of respiratory sarcoidosis. However, as the radiological changes progress, the number of granulomas increased and there was a direct correlation between the number of granulomas in the biopsy specimen and the X-ray staging by Wurm (r = 0.24; p <0.05), while the frequency of granulomas with necrosis also increased (r = 0.39 ; p < 0.05).

Keywords

• саркоидоз
• морфологическое строение гранулемы
• лучевые стадии