The state of intestinal microbiocenosis in children with Helicobacter pylori-associated duodenal ulcer

Abstract

Background. Duodenal ulcer (DU) in children is a serious problem in clinical medicine. At present, the main cause of DU is considered to be infection of the mucous membrane with H.pylori. Data from the scientific literature on quantitative and qualitative changes in the intestinal microflora differ. The purpose was to analyze the state of intestinal microbiocenosis in children with Helicobacter pylori-associated duodenal ulcer. Materials and methods. A comprehensive clinical and instrumental-laboratory examination of 90 children aged 7–18 years with DU associated with H.pylori was conducted. The classical method of seeding faeces was used. Results. Among children with DU, 90 out of 110 patients were infected with H.pylori, which is 81.8 %. In patients with DU associated with H.pylori, the detection of bifidobacteria, lactobacilli, enterobacteria of the genus Pantoea is significantly reduced against the background of increased opportunistic anaerobic bacteria of the genus Clostridium, P.niger, facultative anaerobic and aerobic enterotoxigenic and enteropathogenic escherichia and opportunistic proteas and staphylococci. The most common deviations are those towards growth of yeast-like fungi of the genus Candida. Conclusions. The prevalence of H.pylori in children with DU is 81.8 %. In most children with this pathology, various disorders of the intestinal microflora are registered, which can complicate the course, aggravate the chronicity of the process, reduce the effectiveness of antihelicobacter therapy.

Keywords

• children, peptic ulcer disease, helicobacter pylori, microbiocenosis