The effect of furazolidone on the growth of broilers and detection of its residues in tissues by hplc

Abstract

Three experiments were conducted to examine the effect of furazolidone on the growth performance of broiler chickens and residue level and excrection time in edible meat, liver and kidney samples. In experiment 1, 240 day-old chicks were assigned to four groups with dietary treatmens including various levels (0, '5, 15, and 45 mg//kg feed) of furazolidone. The diets were fed to 4'2 days old and and growth performance of the groups were determined. In experiment 2, 45 chickens, 42 days old, in 3 groups were given furazolidone 0, 100, 200 mg/'kg feed iior 10 days. In experiment 3, two groups dhickens, each had 15 chickens, were feed furazolidone 300 and 500 mg/kg feed for 5 days as a curative dose. No benefical effects of dietary furazolidone on live weights but decreased feed intake. Two chickens / group / day were slaughtered during the 7 days after withdrawal of furazolidone to determine residue levels. Furazolidone residues were analysed in kidney, liver and muscles by using HPLC. In experiment 1, furazolidone residues were detected during the 7 days in kidney and liver samples and 3 days in muscles. In experiment 2, the residues were disappered at day 6 in kidney and liver samples and day 4 in muscles. But in experiment 3, the drug were not excreted from the tissues even at the end of the 7 days.