Nature Communications (Apr 2022)

ComFC mediates transport and handling of single-stranded DNA during natural transformation

  • Prashant P. Damke,
  • Louisa Celma,
  • Sumedha M. Kondekar,
  • Anne Marie Di Guilmi,
  • Stéphanie Marsin,
  • Jordane Dépagne,
  • Xavier Veaute,
  • Pierre Legrand,
  • Hélène Walbott,
  • Julien Vercruyssen,
  • Raphaël Guérois,
  • Sophie Quevillon-Cheruel,
  • J. Pablo Radicella

DOI
https://doi.org/10.1038/s41467-022-29494-z
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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The ComFC protein is essential for natural transformation, a process that plays a major role in the spread of antibiotic resistance genes. Here the authors show that ComFC is a membrane-associated protein that participates in the transport of DNA through the cell membrane and the handling of the single-stranded DNA once delivered into the cytoplasm.