Journal of Ophthalmology (Jan 2016)

Comparison of the Early Clinical Outcomes between Combined Small-Incision Lenticule Extraction and Collagen Cross-Linking versus SMILE for Myopia

  • Alex L. K. Ng,
  • Tommy C. Y. Chan,
  • George P. M. Cheng,
  • Vishal Jhanji,
  • Cong Ye,
  • Victor C. P. Woo,
  • Jimmy S. M. Lai

DOI
https://doi.org/10.1155/2016/2672980
Journal volume & issue
Vol. 2016

Abstract

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Background. To compare the early outcome of combined SMILE and collagen crosslinking (SMILE Xtra) with SMILE. Method. Prospective, comparative interventional study of 21 eyes receiving SMILE Xtra using a low energy protocol and 32 control eyes receiving SMILE only. The outcomes were compared at 1, 3, and 6 months postoperatively. Results. Both groups had myopia with spherical equivalent refraction (SEQ) > 4.00 D. The SMILE Xtra group had thinner preoperative central corneal thickness and residual stromal bed thickness (p<0.021). At 6 months, no eyes lost more than 1 line in corrected distance visual acuity. The safety index was 0.96±0.06 and 1.00±0.00 in SMILE Xtra and control, respectively (p<0.001). 89% and 94% of eyes were within ±0.50 D of target refraction, respectively, with the mean error in SEQ correction being -0.17±0.26 D for SMILE Xtra and +0.03±0.25 D for control (p=0.021). The efficacy index was 0.88±0.13 and 0.97±0.06, respectively (p=0.005). Conclusion. SMILE Xtra had good overall safety profile and predictability at 6 months. However, when compared with control, the safety index and efficacy index were statistically significantly lower in the early postoperative period.