Nature Communications (Apr 2022)
Collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium
- Qian Li,
- Shang Chen,
- Kui Zhu,
- Xiaoluo Huang,
- Yucheng Huang,
- Zhangqi Shen,
- Shuangyang Ding,
- Danxia Gu,
- Qiwen Yang,
- Hongli Sun,
- Fupin Hu,
- Hui Wang,
- Jiachang Cai,
- Bing Ma,
- Rong Zhang,
- Jianzhong Shen
Affiliations
- Qian Li
- National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University
- Shang Chen
- National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University
- Kui Zhu
- National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University
- Xiaoluo Huang
- Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
- Yucheng Huang
- National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University
- Zhangqi Shen
- National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University
- Shuangyang Ding
- Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety, Laboratory of Quality & Safety Risk Assessment for Animal Products on Chemical Hazards (Beijing), Ministry of Agriculture and Rural Affairs
- Danxia Gu
- Centre of Laboratory Medicine, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College
- Qiwen Yang
- Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Hongli Sun
- Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Fupin Hu
- Institute of Antibiotics, Huashan Hospital, Fudan University
- Hui Wang
- Department of Clinical Laboratory, Peking University People’s Hospital
- Jiachang Cai
- Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang
- Bing Ma
- Clinical Laboratory, Medicine Department, Henan Provincial People’s Hospital
- Rong Zhang
- Department of Clinical Laboratory, Second Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang
- Jianzhong Shen
- National Center for Veterinary Drug Safety Evaluation, College of Veterinary Medicine, China Agricultural University
- DOI
- https://doi.org/10.1038/s41467-022-29493-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The acquisition of resistance to one antibiotic sometimes leads to collateral sensitivity to a second antibiotic. Here, the authors show that vancomycin resistance in Enterococcus faecium is associated with a remarkable increase in susceptibility to pleuromutilin antibiotics, such as lefamulin.
