Clinical, Cosmetic and Investigational Dermatology (Apr 2022)
Role of Fetuin-A in the Pathogenesis of Psoriasis and Its Potential Clinical Applications
Abstract
Endeshaw Chekol Abebe,1 Zelalem Tilahun Muche,2 Awgichew Behaile T/Mariam,1 Teklie Mengie Ayele,3 Melaku Mekonnen Agidew,1 Muluken Teshome Azezew,2 Edgeit Abebe Zewde,2 Tadesse Asmamaw Dejenie4 1Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 3Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 4Department of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Endeshaw Chekol Abebe, Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, P.O. Box:272, Debre Tabor, 6300, Ethiopia, Tel +251928428133, Email [email protected]: Fetuin-A is a plasma glycoprotein exhibiting multifaceted physiological and pathological functions. It has been determined to be involved in various essential biological functions, such as regulation of calcium metabolism, osteogenesis, and insulin signaling pathway. It also plays a crucial role in the pathogenesis of several disorders, including psoriasis. Psoriasis is a chronic systemic inflammatory disorder caused by a constellation of environmental, immunogenic, and genetic factors. It has been shown that dysregulation of cytokines mediated immune response is responsible for the development of psoriasis. Several recent publications suggest that dysregulation of fetuin-A correlates with psoriasis disease activities, revealing its putative role in the development of psoriasis. Furthermore, clinical application of fetuin-A as a diagnostic marker, prognostic predictor, and therapeutic target for different clinical conditions is in progress, and some are showing promising outcomes. This review primarily focuses on the current understanding of the role of fetuin-A in the pathogenesis of psoriasis and its potential clinical applications, with a brief highlight of psoriasis epidemiology and burden. The information was gathered systematically from various journals via electronic searches using various search engines: PubMed, Google Scholar, HINARI, and Cochrane Library from inception to 2022. The studies involved were restricted to English language. Conversely, articles written in other languages, studies done on fetuin B, or studies conducted on other dermatological diseases were excluded from the review article.Keywords: fetuin-A, role of fetuin-A, psoriasis, pathogenesis, clinical applications
